The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

These volumes provide a large introduction to the works of modern value theory from their beginnings in J. Bentham, F. Nietzsche, and H. Lotze to the more recent Anglo-American studies. Volume I is concerned with "the German-Language Group." Extensive discussion is devoted to the views of F. Brentano, A. Meinong, C. von Ehrenfels, J. C. Kreibig, E. Heyde, H. Rickert, H. Münsterberg, M. Scheler, K. Wiederhold, W. Stern, F. Wilken, M. Beck, and V. Krafts. It provides a good conspectus of (...) varieties of nineteenth century value theories. The author aims at an exposition rather than critical treatment of the various philosophers. Each chapter contains a useful bibliography. Of more contemporary interest is Volume II which deals with the Anglo-American Group. One finds here a detailed presentation of the theories of W. M. Urban, J. Dewey, B. Bosanquet, D. Prall, C. G. Shaw, R. B. Perry, D. H. Parkel, W. Stern, A. C. Garnett, J. N. Findlay, E. Brightman, B. E. Jessup, C. I. Lewis, R. Lepley, S. C. Pepper, Everett Hall, R. Hartman, and W. D. Lamont. Shorter discussions deal with works of A. L. Hillard, E. M. Adams, and K. Aschenbrenner. Liberal quotations from original sources are interspersed throughout the exposition. The clarification of issues is not always successful. The author does provide a good focus, however, for important passages from the works discussed. Regrettably, one finds an omission of the view of David Pole, the absence of a summary section on each theory discussed, and the absence of an index. Nevertheless, the students of value theory can find in this work a useful tool of research. The comprehensive scope provides a rich variety of contributions to the important field of value theory.—A.S.C. (shrink)

Previously we saw that racist prejudice is supported by false history. The false history of the Greek origins of mathematics is reinforced by a bad philosophy of mathematics. There is no evidence for the existence of Euclid. The “Euclid” book does not contain a single axiomatic proof, as was exposed over a century ago. Such was never the intention of the actual author. The book was brazenly reinterpreted, since axiomatic proof was a church political requirement, and used in church rational (...) theology adopted during the Crusades, as a counter to Islamic rational theology. Deductive proofs are MORE fallible than inductive or empirical proofs. Even a validly proved mathematical theorem, such as the “Pythagorean” theorem, is invalid knowledge in the real world. There is no concept of approximate truth in formal mathematics. Nevertheless, the myth of “superior” axiomatic proofs in the “Euclid” book continues to be reiterated by Western historians, and colonial education teaches axiomatic mathematics. Actually, superior practical value comes from the two “Pythagorean” calculations well known toIndian/Egyptian tradition, but unknown to Greeks. The advantage of related decolonized courses in mathematics has been pedagogically demonstrated. But understanding and political will are needed to change colonial/church education. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

Filing charges of scientific misconduct can be a risky and dangerous endeavor. This article presents rules of conduct to follow when considering whether to report perceived misconduct, and a set of step-by-step procedures for responsible whistleblowing that describe how to do so once the decision to report misconduct has been made. This advice is framed within the university setting, and may not apply fully in industrial settings.

Without any systematic data or evidence of a problem, or even a thoughtful analysis of costs and benefits, the application of the human participant review system within universities is overreaching at the same time that some risky experimentation on humans outside of universities is unregulated. This article questions the purpose, feasibility, and effectiveness of current IRB approaches to most "2 people talking" situations and proposes scaling back the regulatory system to increase respect accorded it by researchers and its ability to (...) protect human participants of research from real versus imagined harms. In too many cases, the focus is on form over ethical substance: counting what can be counted, rather than focusing instead on what counts. Some disciplines - oral history and journalism, for example - simply do not belong within the scope of institutional review board jurisdiction. Others, such as survey research, informational interviews, and informal interactions, call for a shift from centralized review to more departmentally based (i.e., rooted in disciplinary ethics) oversight, and clearer guidelines on what requires advance review as opposed to provision of post hoc complaint systems. (shrink)

Charles Ogden (1889-1957) is best known as the senior author of The Meaning of Meaning, the inventor of the 850-word system of Basic English and the expositor of the writings of Jeremy Bentham. Bentham's work had confirmed Ogden in the conviction he had nurtured for 20 years: that language, for all its pitfalls, could be controlled, thus ensuring effective communication and international understanding, perhaps even preventing war.

“Multiple modernities” is not a novel theme, as the editors and contributors amply concede in the volume. At its best, the conception is an invitation to ever more openness to the possibilities of...

Ogden spent over forty years attempting "to deal... with the whole of the linguistic problem." This study gives his work an enduring quality which is of particular relevance to late twentieth century linguistics.

C. K. Grant; X*—On a Definition of Knowledge, Proceedings of the Aristotelian Society, Volume 73, Issue 1, 1 June 1973, Pages 157–166, https://doi.org/10.1093/a.

To eliminate racist prejudices, it is necessary to identify the root cause of racism. American slavery preceded racism, and it was closely associated with genocide. Accordingly, we seek the unique cause of the unique event of genocide + slavery. This was initially justified by religious prejudice, rather than colour prejudice. This religious justification was weakened when many Blacks converted to Christianity, after the trans-Atlantic slave trade. The curse of Kam, using quick visual cues to characterize Blacks as inferior Christians, was (...) inadequate. Hence, the church fell back on an ancient trick of using false history as secular justification for Christian superiority. This trick had resulted in a false history of science during the Crusades when scientific knowledge in translated Arabic texts was indiscriminately attributed to the early Greeks, without evidence. This false history enabled belief in religious superiority to mutate into a secular belief in White superiority. After colonialism, and the Aryan race conjecture, the belief in White superiority further mutated into a belief in Western civilizational superiority, openly propagated today by colonial education. Hence, to eliminate racist prejudice, it is necessary to engage simultaneously with the allied prejudices about Christian/White/Western superiority, based on the same false history of science. (shrink)

Two cases of carcinoma of the stomach presenting during the same month and dying within four weeks of one another less than one year later are presented. One was treated symptomatically and the other received radical surgery. The care they received depended on decisions about diagnosis and treatment; the outcomes of these and the difficulties involved in evaluating monetary costs and quality of care are discussed in the light of recent interest in medical audit.

We send messages as much in how we communicate as by what we communicate. Learning best practices, such as those for data management proposed in the accompanying article, are components of becoming a responsible and contributing member of the community of scholars. Not only must we teach the principles underlying best practices, we should model and teach approaches for implementing those practices and help students come to view them within the larger context of becoming members of a professional community. How (...) to collaborate across differences and how to have disputes professionally are skills all professionals need, and they should be taught along with the content itself. (shrink)

In one way or another the theory and practice of modern medicine is confronting us with many dilemmas, chiefly, though not exclusively, of a moral character; the transplantation of organs, abortion, and euthanasia are examples, and closely associated with these are more obviously conceptual problems such as the definition of death and, for that matter, of life itself. Contemporary moral philosophers have been strangely silent on these matters, and have been content to leave the field to lawyers and churchmen and (...) those few medical men both able and willing to reflect upon their practices. (shrink)